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Xtreme Couture Athletic Pharmaceuticals’ products are completely natural, made from vegetable cultures, and will not produce a positive performance enhancing drug test.
The intestinal absorption of Vitamin B12 is more complex than the other B vitamins, involving acidic cleavage from Vitamin B12 carriers, binding proteins and intrinsic factor mediated intestinal absorption.
Due to this complexity in absorption, and relatively low amounts in processed foods, many individuals are functionally deficient in Vitamin B12.
Vitamin B12 is an essential vitamin involved in methylation reactions, fatty acid metabolism, DNA and RNA synthesis.
Vitamin B6 plays is involved in hormonal synthesis, neurotransmitter synthesis, and red blood cell metabolism.
Folate is and vitamin B12 work together in metabolic processes including the folate cycle and formation of S-Adenosyl-methionine (SAM), the principle methyl donor in the body. SAM is the principle methyl donor for multiple cellular reactions, including biosynthesis of proteins, neurotransmitters, hormones, phospholipids, creatine, and DNA methylation (1). In states of folate or vitamin B12 deficiency, SAM will not be activated for methylation reactions, leading to a decline in physiological function. This allows for a build up of homocysteine, which is a moderate risk factor for cardiovascular disease (2). Disruptions in the folate cycle can lead to decreased glutathione production, which is the body’s main intracellular antioxidant (1).
1) James et al. Abnormal Transmethylation/transsulfuration Metabolism and DNA Hypomethylation Among Parents of Children with Autism. J Autism Dev Disord. Springer Science+Business Media, LLC 2008
2) Kauwell. Epigenetics: What It Is and How It Can Affect Dietetics Practice. Journal of the American Dietetic Association (2008) vol. 108 (6) pp. 1056-1059
B12 Nitro is a tasty sublingual delivery form of B12, Folate, and B6 which has been shown to be an effective way to deliver these important nutrients.