Xtreme Couture Athletic Pharmaceuticals
Xtreme Couture Athletic Pharmaceuticals O2 Plus+ - XCP-2005
O2 Plus+ XCP-2005
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Xtreme Couture Athletic Pharmaceuticals O2 Plus+ - XCP-2005

*Vegetable Culture consists of: Peas, Lentils, Lima Beans

These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, cure or prevent disease.

Xtreme Couture Athletic Pharmaceuticals’ products are completely natural, made from vegetable cultures, and will not produce a positive performance enhancing drug test.

Use  O2 Plus+ to increase endurance.

Most athletes take 5 to 6 tablets 1 hour before practice or competition.  Fighters commonly take 5 tablets 1 hour before the fight and another 5 tablets 30 minutes before the fight.

The creation of this product’s vegetable culture is a patented process, unique to XCAP.

When the research came out of the Soviet Union, XCAP saw the value of having a product that served as a methyl donor and created O2 Plus+.

In short the product is Methyl Donors and Acceptors (which means moving a single carbon in living systems)

One (1) tablet three (3) times each day as a dietary supplement or as otherwise recommended by your healthcare professional.

180 Tablets

OOrganik-15, Cellulose, Stearic Acid, Food Glaze, Betaine Anhydrous and Magnesium Stearate

EDUCATION CENTER (Click On Topic Below To See More)
   • Detailed Product Description  

Detailed Product Description

O2 Plus+ is a product that contains methyl donors and acceptors organically complexed in vegetable culture( peas, lentils, lima beans).

Each tablet contains mixed cultured vegetables with biologically active, methyl related culture concentrates, along with natural organically bound trace elements and enzymes.

The creation of this product’s vegetable culture is a patented process, unique to XCAP.

Methyl groups are one-carbon portions of biosynthetic material within the cell. Such reactions include the synthesis of creatine (important in muscle contraction), adrenalin (involved in biological oxidation), steroids (hormone metabolism, synthesis of vitamin D and cholesterol), and lecithin (essential for the emulsification of cholesterol), as well as the methylation-mediated deactivation of toxic compounds.

Very important is the fact that energy from methyl groups does not follow the glucose or Krebs cycle; these groups are combusted by way of a faster, alternate root. In the absence of methyl donors, such groups are still demanded, but are taken at the expense of proteins, which carry these groups and their precursors.

Further, methyl donors help to spare methionine—the scarcest of all essential aminoacids. “24

When looking for research to help better understand this product, we have to look at methyl donors in general because O2 Plus+ is a unique product. To understand it, it would be valuable to know a little about pangamic acid.

Pangamic acid was first isolated in 1951 by Drs. Ernest Krebs, Sr. and Jr., from apricot kernels, along with laetrile, which is also known as vitamin B17. Pangamic acid and laetrile are methyl donors.

The original interest in this type of product began with research into pangamic acid, or vitamin B 15 , done in the old Soviet Union. Pangamic acid is a methyl donor and the Soviets found it to be valuable for enhancing sports performance1,2,3,4. Soviet scientists had shown that pangamic acid supplementation can reduce the buildup of lactic acid in athletes and thereby lessen muscle fatigue and increase endurance.

It was also used to treat a variety of problems including alcoholism, dementia, schizophrenia, heart disease, diabetes, high blood pressure, skin diseases, and chemical poisonings in the Soviet Union.

Because of both its circulatory stimulus and its antioxidant effect, vitamin B15 has been used in Europe to treat premature aging. Some believe it has the ability to protect from pollutants, especially carbon monoxide.

In the US, pangamic acid is banned by the FDA, as is laetrile. This action was taken more because of fantastic claims by the proponents of the supplements than because of any problems or toxicity with them. Pangamic acid is found in many foods. Whole grains, like brown rice, pumpkin seeds, and sunflower seeds all contain pangamic acid.

Since the FDA banned pangamic acid, dimethylglycine (DMG) has been used by some people as a substitute. Some believe that DMG intake can increase pangamic acid production. Pangamic acid is a combination of DMG and gluconic acid. It is thought that the DMG is the active component of pangamic acid. DMG was shown to reduce ulcer size and number of gastric ulcers in rats20. DMG, in another animal study, showed a protective effect against strychnine induced seizures21. DMG also shows promise for helping to boost the immune system22,23.

But its proponents use it mainly for improvement of athletic performance, because that was the focus of the early Soviet research.

Dr. William Ellis writes about dimethylglycine, “A well-publicized methyl donor product on the market today is dimethylglycine.” This is a relatively well known source of methyl groups, but also a relatively poor quality one. Dimethylglycine is also known to be mutagenic in vitro and therefore probably dangerous as a food supplement.

Naturally-occurring methyl-related compounds, as found in vegetables are sources of both donors and acceptors. This allows for the extraction of more energy per methyl group. In addition, the naturally occurring compounds provide more methyl groups than similar amounts of dimethylglycine. There is no equivalent product to O2plus+ produced by any other company.” 24

When the research came out of the Soviet Union, XCAP saw the value of having a product that served as a methyl donor and created O2 Plus+.

The benefits of pangamic acid and dimethylglycine are from their activity as methyl donors, and XCAP created a methyl donor complexed in a vegetable culture—making them safer and more effective.

There are many methyl donors, and there is much research that supports their value. The conversion of homocysteine to methionine in the body is a methlyation reaction.

Betaine (which is trimethylglycine) and dimethylglycine, both methyl donors, have been shown to have an effect in lowering homocysteine in rats5. Researchers found an inverse relationship between homocysteine levels and betaine levels in pregnant women6. Researchers in the Netherlands also found a connection between betaine levels and reduced homocysteine, and that folate

supplementation increased plasma betaine concentration. They postulated that there are two related pathways for the methlyation of homocysteine7.

Betaine supplementation can interfere with the induction of experimental cholestasis and changes in the metabolism of sulfur amino acids associated with administering a toxin to mice8. Similarly, betaine can prevent liver damage induced by alcohol or other toxins9,10,11.

S-Adenosylmethionine, also known as SAM-e is another methyl donor. It has been shown to be effective for depression in AIDs patients12. Animal studies have also shown SAM-e to be protective of the liver and increases the antioxidant effects of glutathione and generally protect against chemical toxicity13,14,15,17. Unfortunately, SAM-e is expensive and unstable.

Methyl donors may be protective against cancer. One of the mechanisms for the cancer preventive capabilities of folic acid is the fact that it aids in methylation16.

Similarly, the B6 has a protective effect in colorectal cancer because of its role in methylation19. A lot of cancer research centers around DNA methylation.

Hypomethylation creates cancer risk18, and aberrant methlyation also creates problems. This research may mean that having a natural food source as a methylation product is especially important.

The nutrients that aid in methylation have many health benefits. Research shows that there is potential value for cardiovascular health, detoxification, protection of the liver, immune enhancement, mental health, protection against free radical pathology and sports performance.

One of the major uses of O2 Plus+ is to increase athletic performance. By complexing the methyl donors with food, XCAP has made a safer and more effective product.

1. Vopr Pitan 1966 May-Jun;25(3):7-11 An analysis of the influence exerted by pangamic acid (vitamin B 15) on the carbohydrate-phosphorus metabolism in muscle activity
2. Ukr Biokhim Zh 1969;41(3):269-75 Mechanism of the effect of physical work on cholesterol metabolism. Effect of prolonged administration of pangamic acid (vitamin B 15) on muscle chemism
3. Vopr Med Khim 1969 Jan-Feb;15(1):60-4 Distribution of injected pangamic acid (vitamin B 15) in the organism and its effect on oxidative metabolism of the brain.
4. Tsitologiia 1969 Nov;11(11):1427-33 Effect of pangamic acid on oxidative phosphorylation in skeletal muscle mitochondria
5. J Nutr Biochem 2004 Nov;15(11):666-71 Effects of intravenous betaine on methionine-loading-induced plasma homocysteine elevation in rats.
6. Am J Clin Nutr 2005 Jun;81(6):1383-9 Plasma choline and betaine and their relation to plasma homocysteine in normal pregnancy.
7. Am J Clin Nutr 2005 Jun;81(6):1378-82 Betaine concentration as a determinant of fasting total homocysteine concentrations and the effect of folic acid supplementation on betaine concentrations
8. Food Chem Toxicol 2005 May;43(5):663-70 Effect of betaine supplementation on changes in hepatic metabolism of sulfur-containing amino acids and experimental cholestasis induced by alphanaphthylisothiocyanate.
9. J Nutr 2005 Mar;135(3):519-24 A comparison of the effects of betaine and S-adenosylmethionine on ethanol induced changes in methionine metabolism and steatosis in rat hepatocytes
10. Amino Acids 2004 Oct;27(2):199-205 Betaine or taurine administration prevents fibrosis and lipid peroxidation induced by rat liver by ethanol plus carbon tetrachloride intoxication.
11. Exp Toxicol Pathol 2004 Jul;55(6):505-9 The effect of betaine treatment on triglyceride levels and oxidative stress in the liver of ethanol-treated guinea pigs.
12. BMC Psychiatry 2004 Nov 11;4(1):38 S-adenosylmethionine (SAM-e) for the treatment of depression in people living with HIV/AIDS
13. Carcinogenesis 1996 Jul;17(7):1533-7 Persistent chemopreventive effect of S-adenosyl-L-methionine on the development of liver putative preneoplastic lesions induced by thiobenzamide in diethylnitrosamineinitiated rats.
14. Free Radic Biol Med 2004 May 15;36(10):1303-16 Antioxidant properties of S-adenosyl-L-methionine in Fe(2+) initiated oxidations
15. Mutat Res 2003 Jul 25;528(1-2):61-74 S-adenosyl-L-methionine is able to reverse micronucleus formation induced by sodium arsenite and other cytoskeleton disrupting agents in cultured human cells
16. J Nutr 2000 Feb;130(2):129-32 Folate and carcinogenesis: an integrated scheme
17. Am J Clin Nutr 2004 Sep;80(3):539-49 Betaine in human nutrition.
18. Breast Cancer Research; May 21, 2004 Vol. 6, #4 Chemically Induced DNA Hypomethylation in Breast Carcinoma Cells Detected by the Amplification of Intermethylated Sites
19. Gastroenterology 2005 Jun;128(7):1830-7 Vitamin B6 intake, alcohol consumption, and colorectal cancer: a longitudinal population-based cohort of women
20. J Pharm Pharmacol 2000 Dec;52(12):1519-22 Effect of dimethylglycine on gastric ulcers in rats.
21. Pharmacol Biochem Behav 1985 Apr;22(4):641-3 Prevention of strychnine-induced seizures and death by the N methylated glycine derivatives betaine, dimethylglycine and sarcosine.
22. J Lab Clin Med 1990 Apr;115(4):481-6 Stimulation of the immune response by dimethylglycine, a nontoxic metabolite
23. J Infect Dis 1981 Jan;143(1):101-5 Immunomodulating properties of dimethylglycine in humans.
24. Tomorrow’s Nutrition and Health Care for Tomorrow by Dr. William A. Ellis, copyright 1982 International Preventive Medicine Foundation


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Statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent disease.